Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.


AYYILDIZ T., Dolar E., UĞRAŞ N., Dizdar O. S. , BALABAN ADIM Ş., YERCİ Ö.

Asian Pacific journal of cancer prevention : APJCP, vol.15, no.11, pp.4711-6, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.11.4711
  • Journal Name: Asian Pacific journal of cancer prevention : APJCP
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.4711-6
  • Keywords: Adiponectin, Adipo R1, Adipo R2, gastric carcinoma, survival, prognosis, CIRCULATING ADIPONECTIN, PLASMA ADIPONECTIN, PROSTATE-CANCER, BREAST-CANCER, CELL, GROWTH, RISK, METASTASIS, CARCINOMA, CLONING

Abstract

Introduction: Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer. Objectives: The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival. Materials and Methods: Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study. Results: Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Conclusion: Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.