The histopathological and morphometric investigation of the effects of systemically administered humic acid on alveolar bone loss in ligature-induced periodontitis in rats

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Calisir M., Akpınar A., Poyraz Ö., Goze F., Çınar Z.

JOURNAL OF PERIODONTAL RESEARCH, vol.51, pp.499-507, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 51
• Publication Date: 2016
• Doi Number: 10.1111/jre.12329
• Journal Name: JOURNAL OF PERIODONTAL RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.499-507
• Keywords: alveolar bone loss, experimental periodontitis, humic acid, inflammatory cytokines, INFLAMED GINGIVAL TISSUE, NECROSIS-FACTOR-ALPHA, INFLAMMATORY MEDIATORS, ANTAGONISTS INHIBIT, CLINICAL-PARAMETERS, CYTOKINE PROFILES, DISEASE, SERUM, INTERLEUKIN-1-BETA, PATHOGENESIS
• Bursa Uludag University Affiliated: No

Abstract

BackgroundHumic acid is a soil extract found widely around the world. This product includes some trace elements important for human's health. The purpose of this study was to evaluate the morphometric and histopathological changes associated with an experimental periodontitis model in rats in response to systemic administration of humic acid.