ELISA screening results for HAV, HBV, HCV, HIV: A retrospective study
Pakistan Journal of Medical Sciences, cilt.42, sa.10, ss.2722-2728, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 10
- Basım Tarihi: 2026
- Doi Numarası: 10.12669/pjms.42.10.16995
- Dergi Adı: Pakistan Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.2722-2728
- Anahtar Kelimeler: Enzyme-linked immunosorbent assay (ELISA), Hepatitis A virus (HAV), Hepatitis C virus (HCV), Hepatitis-B virus (HBV), Human immunodeficiency virus (HIV)
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Objective: To retrospectively evaluate the hepatitis A, B, C, and human immunodeficiency virus screening results using the ELISA method in primary care. Methodology: This study was conducted retrospectively using the available recorded data of individuals registered with the Bursa Uludag University Family Health Center who underwent ELISA measurement between January 2020 to December 2024. The study included data from a total of 2,918 individuals over the age of 18 who met the inclusion criteria. In statistical comparisons, α was taken as 0.05. Data analysis was performed using the IBM SPSS Statistics 28 statistical package program. Results: Of the 2918 individuals who participated in the study, 1528 (52.4%) were female, and 1390 (47.6%) were male. The median age of the participants was 24 (18-83). Of the participants, 1355 (46.4%) were healthcare workers, while 1563 (53.6%) were not. Hospital referrals were made in 37 (1.3%) individuals, while 2881 (98.7%) were not referred. Anti-HAVIgM and HBsAg positivity was significantly higher in the non-healthcare worker group compared to the healthcare worker group (p=0.013, p=0.038). Anti-HBcIgG, anti-HBs positivity, and Hepatitis-B vaccination were higher in the healthcare worker group (p<0.001). There was a statistically significant difference between HBsAg and anti-HBs (p<0.001). Hospital referral rates were higher in those positive for Hepatitis A, B, C, and HIV antibodies, while they were significantly lower in those with anti-HBs positivity and those vaccinated against Hepatitis-B (p<0.001). Conclusion: ELISA screenings, Hepatitis-B antibody levels and vaccination status were higher in healthcare workers, while Hepatitis-B antigen levels were higher in non-healthcare workers. Hospital referral rates were also higher in those with high Hepatitis A, B, C, and HIV antibody levels. Our ELISA screening results for infections in family medicine are important for diagnosis, treatment, follow-up, and referral to other clinics.