Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis.

Uz E., Mustafa C., Topaloglu R., Bilginer Y., Dursun A., Kasapcopur O., ...More

Arthritis and rheumatism, vol.60, pp.3410-2, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2009
  • Doi Number: 10.1002/art.24956
  • Journal Name: Arthritis and rheumatism
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3410-2
  • Bursa Uludag University Affiliated: No

Abstract

Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.