Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent

EREN E., EDGÜNLÜ T., Korkmaz H. A., Cakir E. D. P., Demir K., ÇETİN E. S., ...Daha Fazla

GENE, cilt.541, sa.2, ss.101-106, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 541 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.gene.2014.03.013
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.101-106
  • Anahtar Kelimeler: Gynecomastia, Puberty, Estrogen, Leptin, Polymorphism, PROGESTERONE-RECEPTORS, DOMINANT TRANSMISSION, AROMATASE-ACTIVITY, ER-ALPHA, ASSOCIATION, EXPRESSION, POLYMORPHISM, EXCESS, MUTATIONS, CARCINOMA
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Gynecomastia is a benign breast enlargement in males that affects approximately one-third of adolescents. The exact mechanism is not fully understood; however, it has been proposed that estrogen receptors and aromatase enzyme activity may play important roles in the pathogenesis of gynecomastia. While many studies have reported that aromatase enzyme (CYP19) gene polymorphism is associated with gynecomastia, only one study has shown a relationship between estrogen receptor (ER) alpha and beta gene polymorphism and gynecomastia. Thus, the aim of this study was to evaluate the relationships between CYP19 (rs2414096), ER alpha (rs2234693), ER beta (rs4986938), leptin (rs7799039), and leptin receptor (rs1137101) gene polymorphisms and gynecomastia.