Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent


EREN E., EDGÜNLÜ T., Korkmaz H. A. , Cakir E. D. P. , Demir K., ÇETİN E. S. , ...More

GENE, vol.541, no.2, pp.101-106, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 541 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.gene.2014.03.013
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.101-106
  • Keywords: Gynecomastia, Puberty, Estrogen, Leptin, Polymorphism, PROGESTERONE-RECEPTORS, DOMINANT TRANSMISSION, AROMATASE-ACTIVITY, ER-ALPHA, ASSOCIATION, EXPRESSION, POLYMORPHISM, EXCESS, MUTATIONS, CARCINOMA

Abstract

Objective: Gynecomastia is a benign breast enlargement in males that affects approximately one-third of adolescents. The exact mechanism is not fully understood; however, it has been proposed that estrogen receptors and aromatase enzyme activity may play important roles in the pathogenesis of gynecomastia. While many studies have reported that aromatase enzyme (CYP19) gene polymorphism is associated with gynecomastia, only one study has shown a relationship between estrogen receptor (ER) alpha and beta gene polymorphism and gynecomastia. Thus, the aim of this study was to evaluate the relationships between CYP19 (rs2414096), ER alpha (rs2234693), ER beta (rs4986938), leptin (rs7799039), and leptin receptor (rs1137101) gene polymorphisms and gynecomastia.