Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins

VATAN Ö., Bilaloglu R., TUNCA B., ÇEÇENER G., GEBİTEKİN C., EGELİ Ü., ...Daha Fazla

TUMORI J, cilt.93, sa.5, ss.473-477, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 5
  • Basım Tarihi: 2007
  • Dergi Adı: TUMORI J
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.473-477
  • Anahtar Kelimeler: k-ras codon 12 mutation, non-small cell lung cancer, p53 mutation, surgical margins, RESECTED STAGE-I, PROGNOSTIC MARKER, CANCER, GENE, RECURRENCE, EXPRESSION, SMOKING, PREDICT, SERA, RISK
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Aims and background: Lung cancer is one of the most common cancers and has became a predominant cause of cancer-related death throughout the world. The k-ras codon 12 mutation, which is the most common lung cancer mutation, is found in 15 to 30% of all lung cancers. Furthermore, the p53 gene has a very important role in the biological properties of tumor cells, and it is mutated in about 50% of non-small cell lung cancers. Residual tumor cells remain in surgical margins diagnosed as tumor free by histopathological techniques, and they can play a role in forming any local recurrence. Molecular methods may be exploited that are sensitive enough to detect small numbers of tumor cells.