Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones

Guvenc G., Altinbas B., Kasikci E., Ozyurt E., Bas A., UDUM D., ...Daha Fazla

ANDROLOGIA, cilt.51, sa.11, 2019 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 11
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/and.13410
  • Dergi Adı: ANDROLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: hypothalamic-pituitary-gonadal axis, intracerebroventricular, male sex hormones, nesfatin-1, phoenixin, LUTEINIZING-HORMONE, GONADOTROPIN-SECRETION, FOOD-INTAKE, PEPTIDE, BRAIN, NUCB2/NESFATIN-1, TESTOSTERONE, NEUROPEPTIDE, EXPRESSION, PUBERTY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.