Twist beam rear suspension systems are frequently used in front wheel drive cars owing to their compactness, lightweight and cost-efficiency. Since the kinematic behavior of twist beam rear suspension systems are determined by the elastic properties of the twist beam, the twist beam is the most critical component of this suspension system. In the study, a simplified optimization model is presented to offer designers the most suitable beam structure in the early stage of the vehicle system development. With the optimization model, designers will be able to obtain the most suitable twist beam structure in a very short time. Opposite wheel travel analysis based on finite element modeling of twist beam is conducted to examine the kinematic performance of the twist beam rear suspension. The cross-section, position and direction of the twist beam are the most important parameters affecting the performance of the twist beam rear suspension system. In this study, optimization studies with 25 design variables including variable cross-sections, twist beam position and twist beam orientation are performed. Nine different optimization studies are carried out to investigate the effects of design variables better. In optimization studies carried out with the genetic algorithm, the objective and constraint functions are obtained with the moving least squares meta-modeling method. In the study, toe angle, camber angle and roll steer are decided as constraints, and mass as the objective function. With the optimization models, lightweight designs up to 25% have been obtained according to the initial design. It is validated that the proposed simplified model and analysis of twist beam rear suspension with connecting bushing is a quite efficient approach in terms of accuracy and to speed up the optimum design process.