Glutathione S-Transferase M1 and T1 Gene Polymorphisms Are Not Associated with Increased Risk of Gestational Diabetes Mellitus Development
WEST INDIAN MEDICAL JOURNAL, vol.63, no.4, pp.300-306, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 63 Issue: 4
- Publication Date: 2014
- Doi Number: 10.7727/wimj.2013.128
- Journal Name: WEST INDIAN MEDICAL JOURNAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.300-306
- Bursa Uludag University Affiliated: Yes
Abstract
Aim: The aim of this study was to investigate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) gene polymorphisms contributed to development of gestational diabetes mellitus (GDM). Subjects and Methods: Fifty women with diagnosis of GDM and 50 control individuals without GDM or altered glucose intolerance during their pregnancy were enrolled in the study. Multiplex polymerase chain reaction-restriction fragment length polymorphism method was applied to determine the GSTM1 and GSTT1 gene polymorphisms. Genotypes were determined according to bands detected with the agarose gel electrophoresis. Results: The difference in the frequencies of GSTM1 null genotypes between GDM and control groups was not statistically significant (60% and 54%, respectively). There was no statistically significant difference between GDM and control groups with respect to GSTT1 null genotype rates (22% and 20%, respectively). Conclusion: This study shows no association between GST gene polymorphisms and GDM.