Effects of citicoline administration on synaptic proteins in rapid movement rats


ÇAKIR A., ÖCALAN B., KOÇ C., SÜYEN G., CANSEV M., KAHVECİ N.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.25, no.5, pp.562-568, 2022 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.22038/ijbms.2022.60756.13462
  • Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Index Islamicus, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.562-568
  • Keywords: Citicoline, Postsynaptic density, protein-95, REM sleep, Sleep deprivation, Synapsin, Synapsin I, Synaptophysin, PLUS DOCOSAHEXAENOIC ACID, SLEEP-DEPRIVATION, CDP-CHOLINE, FUNCTIONAL RECOVERY, NERVE REGENERATION, GENE-EXPRESSION, MEMORY, INVOLVEMENT, METABOLITES, PLASTICITY

Abstract

Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions. Our objective was to explore the effects of Citicoline on hippocampal and cortical synaptic proteins in rapid eye movement (REM) sleep-deprived rats.