Warfarin dose requirement in Turkish patients: the influences of patient characteristics and polymorphisms in CYP2C9, VKORC1 and factor VII.

Yildirim E., Erol K., Birdane A.

Hippokratia, vol.18, pp.319-27, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2014
  • Journal Name: Hippokratia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.319-27
  • Keywords: Warfarin, CYP2C9, VKORC1, factor VII, polymorphism, CYTOCHROME P4502C9 POLYMORPHISMS, GENETIC-POLYMORPHISM, DOSING ALGORITHMS, BODY-WEIGHT, FACTOR-II, ANTICOAGULATION, PHARMACOGENOMICS, ASSOCIATION, SENSITIVITY, GENOTYPE
  • Bursa Uludag University Affiliated: No

Abstract

Background: To determine the contribution of cytochrome P4502C9 (CYP2C9), vitamin K epoxide reductase (VKO-RC1) and factor VII genotypes, age, body mass index (BMI), international normalized ratio (INR) and other individual patient characteristics on warfarin dose requirements in an adult Turkish population.