CDP-choline modulates matrix metalloproteinases in rat sciatic injury

Gundogdu E. B. , Bekar A. , Turkyilmaz M., Gumus A., Kafa İ. M. , Cansev M.

JOURNAL OF SURGICAL RESEARCH, vol.200, no.2, pp.655-663, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 200 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jss.2015.10.003
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.655-663
  • Keywords: CDP-choline, Sciatic nerve injury, Matrix metalloproteinase, Tissue inhibitors of metalloproteinases, Axonal regeneration, Neuroprotection, PERIPHERAL-NERVE SURGERY, FUNCTIONAL RECOVERY, EXTRACELLULAR-MATRIX, REGENERATION, CYTIDINE, MODEL, METABOLITES, EXPRESSION, SYSTEM, INVOLVEMENT

Abstract

Background: CDP-choline (cytidine-5'-diphosphocholine) improves functional recovery, promotes nerve regeneration, and decreases perineural scarring in rat peripheral nerve injury. The aim of the present study was to investigate the mechanism of action of CDPcholine with regard to matrix metalloproteinase (MMP) activity in the rat-transected sciatic nerve injury model.