CDP-choline modulates matrix metalloproteinases in rat sciatic injury

Gundogdu E. B., Bekar A., Turkyilmaz M., Gumus A., Kafa İ. M., Cansev M.

JOURNAL OF SURGICAL RESEARCH, cilt.200, sa.2, ss.655-663, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 200 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jss.2015.10.003
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.655-663
  • Anahtar Kelimeler: CDP-choline, Sciatic nerve injury, Matrix metalloproteinase, Tissue inhibitors of metalloproteinases, Axonal regeneration, Neuroprotection, PERIPHERAL-NERVE SURGERY, FUNCTIONAL RECOVERY, EXTRACELLULAR-MATRIX, REGENERATION, CYTIDINE, MODEL, METABOLITES, EXPRESSION, SYSTEM, INVOLVEMENT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: CDP-choline (cytidine-5'-diphosphocholine) improves functional recovery, promotes nerve regeneration, and decreases perineural scarring in rat peripheral nerve injury. The aim of the present study was to investigate the mechanism of action of CDPcholine with regard to matrix metalloproteinase (MMP) activity in the rat-transected sciatic nerve injury model.