JOURNAL OF SURGICAL RESEARCH, vol.200, no.2, pp.655-663, 2016 (SCI-Expanded)
Article / Article
JOURNAL OF SURGICAL RESEARCH
Science Citation Index Expanded (SCI-EXPANDED), Scopus
CDP-choline, Sciatic nerve injury, Matrix metalloproteinase, Tissue inhibitors of metalloproteinases, Axonal regeneration, Neuroprotection, PERIPHERAL-NERVE SURGERY, FUNCTIONAL RECOVERY, EXTRACELLULAR-MATRIX, REGENERATION, CYTIDINE, MODEL, METABOLITES, EXPRESSION, SYSTEM, INVOLVEMENT
Bursa Uludag University Affiliated:
Background: CDP-choline (cytidine-5'-diphosphocholine) improves functional recovery, promotes nerve regeneration, and decreases perineural scarring in rat peripheral nerve injury. The aim of the present study was to investigate the mechanism of action of CDPcholine with regard to matrix metalloproteinase (MMP) activity in the rat-transected sciatic nerve injury model.