Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro

Ulukaya E., ARI F., Dimas K., SARIMAHMUT M., Guney E., Sakellaridis N., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.137, no.10, pp.1425-1434, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1007/s00432-011-1021-1
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1425-1434
  • Keywords: Lung cancer treatment, Palladium(II) and platinum(II) complexes, Necrosis, CYTOTOXIC ACTIVITY, CRYSTAL-STRUCTURE, ANTITUMOR AGENTS, CISPLATIN, PD(II), DNA, APOPTOSIS, PT(II), ASSAY, HEPATOTOXICITY
  • Bursa Uludag University Affiliated: Yes

Abstract

Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3).