Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.137, sa.10, ss.1425-1434, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 137 Sayı: 10
- Basım Tarihi: 2011
- Doi Numarası: 10.1007/s00432-011-1021-1
- Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1425-1434
- Anahtar Kelimeler: Lung cancer treatment, Palladium(II) and platinum(II) complexes, Necrosis, CYTOTOXIC ACTIVITY, CRYSTAL-STRUCTURE, ANTITUMOR AGENTS, CISPLATIN, PD(II), DNA, APOPTOSIS, PT(II), ASSAY, HEPATOTOXICITY
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3).