Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections

Aydin M., Ergonul O., Azap A., Bilgin H., Aydin G., Cavus S. A., ...Daha Fazla

JOURNAL OF HOSPITAL INFECTION, cilt.98, sa.3, ss.260-263, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jhin.2017.11.014
  • Dergi Adı: JOURNAL OF HOSPITAL INFECTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.260-263
  • Anahtar Kelimeler: Bloodstream, Gram-negative, Health care, Colistin MIC
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.