EVALUATING CUT-OFF VALUES WITH TIME-DEPENDENT ROC CURVES FOR Ki67


Sigirli D., ERCAN İ., Jin Y., Paksoy E., Tolunay S., Tasdelen I.

PAKISTAN JOURNAL OF STATISTICS, vol.26, no.4, pp.659-671, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2010
  • Journal Name: PAKISTAN JOURNAL OF STATISTICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.659-671
  • Keywords: ROC curve, Time-dependent ROC, Cut-off, Ki67, OPERATING CHARACTERISTIC CURVES, S-PHASE FRACTION, BREAST-CANCER, MEASUREMENT ERROR, PROGNOSTIC VALUE, YOUDEN INDEX, KI-67, MARKERS, AREA, METHODOLOGY

Abstract

Receiver operating characteristic (ROC) curve is one of the most active research areas in medical statistics. While classic ROC curve analysis is a well-established method to study the accuracies of clinical markers, it may be suboptimal for analyzing outcomes over time, such as prognosis. When the outcome variable of interest is an event that occurs not concurrent with the tests, time-dependent ROC curves should be used to accommodate this time lag.