EVALUATING CUT-OFF VALUES WITH TIME-DEPENDENT ROC CURVES FOR Ki67

Sigirli D., ERCAN İ., Jin Y., Paksoy E., Tolunay S., Tasdelen I.

PAKISTAN JOURNAL OF STATISTICS, cilt.26, sa.4, ss.659-671, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2010
  • Dergi Adı: PAKISTAN JOURNAL OF STATISTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.659-671
  • Anahtar Kelimeler: ROC curve, Time-dependent ROC, Cut-off, Ki67, OPERATING CHARACTERISTIC CURVES, S-PHASE FRACTION, BREAST-CANCER, MEASUREMENT ERROR, PROGNOSTIC VALUE, YOUDEN INDEX, KI-67, MARKERS, AREA, METHODOLOGY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Receiver operating characteristic (ROC) curve is one of the most active research areas in medical statistics. While classic ROC curve analysis is a well-established method to study the accuracies of clinical markers, it may be suboptimal for analyzing outcomes over time, such as prognosis. When the outcome variable of interest is an event that occurs not concurrent with the tests, time-dependent ROC curves should be used to accommodate this time lag.