Levels of osteopontin, suppression of tumorgenicity 2 and myeloperoxidase activity in acute coronary syndrome patients with fragmented QRS
Journal of Experimental and Clinical Medicine (Turkey), cilt.40, sa.2, ss.225-231, 2023 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.52142/omujecm.40.2.5
- Dergi Adı: Journal of Experimental and Clinical Medicine (Turkey)
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier
- Sayfa Sayıları: ss.225-231
- Anahtar Kelimeler: acute coronary syndrome, myeleporoxidase, osteopontin, sST2
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
In recent years, studies have focused on new markers to predict the risk of cardiovascular diseases (CVD). There are several studies analyzing biomarkers such as myeloperoxidase (MPO), suppression of tumorgenicity 2 (sST2), and osteopontin (OPN) in CVD, however; there are no studies that show their relationship in patients who have fragmented QRS (fQRS). It aimed to investigate the levels of OPN, sST2, and MPO activity in patients who were diagnosed with acute coronary syndrome (ACS) in the present study. Sixty ACS patients and 26 healthy individuals were included in the study. Patients diagnosed with ACS were divided into two groups; (+)fQRS (n=30) and (-)fQRS (n=30). Levels of OPN and sST2 were measured by ELISA, and MPO activity was measured by colorimetric methods. In ACS patients, serum activity of MPO (33.7 U/L), and levels of OPN (103.29 ng/mL) and sST2 (495.4 pg/mL) were found to be significantly higher than those in the control (23.14 U/L, 42.65 ng/mL, 344.11 pg/mL, respectively; p<0.01, p<0.01, p<0.05). However, there were no significant differences between the activity of MPO, levels of OPN, and sST2 in patients with (+)fQRS (respectively, 32.74 U/L, 101.89 ng/mL and 451.97 pg/mL) and (-)fQRS (respectively, 34.67 U/L, 104.69 ng/mL, 535.73 pg/mL). There were also positive correlations between MPO activity and platelet (r=0.376, p<0.05) levels in the (+)fQRS group, and sST2 and triglyceride levels in (-)fQRS group. When the diagnostic performances for ACS were examined, the sensitivity of CK-MB, troponin-I, MPO, OPN, and sST2 were 83%, 80%, 65%, 85%, 58%, and specificity was 96%, 100%, 72%, 96%, 80%, respectively. In conclusion, MPO, OPN, and sST2 may be included in the factors that may contribute to the diagnosis and development of ACS. In addition, the discovery of the high diagnostic sensitivity and specificity of OPN in acute coronary syndrome is a new finding obtained in this study.