Effect of intracerebroventricularly injected choline on plasma ACTH and beta-endorphin levels in conscious rats


Savci V., Gurun M. S. , Ulus I., Kiran B.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.309, no.3, pp.275-280, 1996 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 309 Issue: 3
  • Publication Date: 1996
  • Doi Number: 10.1016/0014-2999(96)00330-5
  • Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.275-280

Abstract

In the present study, we examined the effect of intracerebroventricularly injected choline on plasma ACTH (adrenocorticotrophin) and beta-endorphin levels in conscious rats. The intracerebroventricularly injection of choline (50-150 mu g) elevated plasma ACTH levels in a dose-dependent manner. Plasma beta-endorphin levels were also significantly increased. Pretreatment of rats with mecamylamine (50 mu g; intracerebroventricularly), the nicotinic receptor antagonist, completely inhibited the ACTH and beta-endorphin response to choline (150 mu g; intracerebroventricularly). An antagonist of the muscarinic receptor, atropine (10 mu g; intracerebroventricularly), failed to alter these effects. Pretreatment of rats with hemicholinium-3 (20 mu g; intracerebroventricularly), a drug which inhibits the uptake of choline into cholinergic neurons, abolished the choline-induced increases in both plasma ACTH and beta-endorphin levels. These results indicate that choline can increase plasma concentrations of ACTH and beta-endorphin through the activation of central nicotinic acetylcholine receptors.