The relationship between intraoperative body temperature and thiol/disulfide balance in geriatric patients undergoing elective transurethral prostate resection surgery with spinal anesthesia


Kazancioglu L., Batcik S., ARPA M., Kazdal H., Koyuncu T., Bilgin H., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.27, no.18, pp.8523-8530, 2023 (SCI-Expanded) identifier identifier identifier

Abstract

OBJECTIVE: We aimed to investigate the relationship between intraoperative body temperature and thiol/disulfide balance in geriatric patients scheduled for elective transurethral prostate resection surgery with spinal anesthesia. PATIENTS AND METHODS: 71 patients classified as categories 1 and 2, according to American Society of Anesthesiologists (ASA) classification, were included in the study. The core temperature of the patients was recorded in the operating room after monitoring, at 5 and 30 minutes after spinal anesthesia. Total thiols, native thiols, disulfide amounts, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated as percentages after monitorization (T-preoperative) and at 60 minutes after spinal anesthesia (T-intraoperative). RESULTS: The disulfide levels in the T-intraoperative period (29 +/- 8.9 mmol/L) were higher than the disulfide levels measured in the T-preoperative period (18.2 +/- 8.8 mmol/L) (p<0.001). In the T-preoperative period, the disulfide/native thiol (%) level was 4.6 +/- 2, while the disulfide/total thiol (%) level was 4.2 +/- 1.6. In the T-intraoperative period, the disulfide/native thiol (%) level was 8 +/- 2.3, while the disulfide/total thiol (%) level was 6.8 +/- 1.7. Native thiol/total thiol (%) levels for the T-preoperative and T-intraoperative periods were 91.5 +/- 3.3 mmol/L and 86.3 +/- 3.4 mmol/L, respectively. A correlation was found between native, total thiol levels and patient age in the T-preoperative and T-intraoperative periods. CONCLUSIONS: Oxidative stress can be reduced in geriatric patients with the possibility of developing involuntary perioperative hypothermia by regularly monitoring body temperature and applying warming techniques.