The role of genetic mutations in intrahepatic cholestasis of pregnancy
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, vol.59, no.5, pp.706-710, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 5
- Publication Date: 2020
- Doi Number: 10.1016/j.tjog.2020.07.014
- Journal Name: TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Page Numbers: pp.706-710
- Bursa Uludag University Affiliated: Yes
Abstract
Objective: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder of pregnancy characterized by pruritus, elevated liver enzymes and fasting serum bile acids. Genetic predisposition has been suggested to play a role in its etiology and mutations in the ATP8B1(OMIM *602397) (FIC1), ABCB11(OMIM *603201) (BSEP), and ABCB4(OMIM *171060) (MDR3) genes have been implicated. In the present study, we aimed to investigate the possible role of ATP8B1, ABCB11, and ABCB4 gene mutations in the patients with ICP.