Recently, spur gears with asymmetric teeth have been considered a way of increasing performance while maintaining the gearbox dimensions. Asymmetric teeth have different pressure angles on drive and coast sides. They provide, among other advantages, a high bending strength and low vibration. In spur gears with asymmetric teeth, wear has been observed to be a major failure mode. In this study, the impact of tip relief modification and pressure angle on the wear of spur gears with asymmetric teeth is numerically investigated. Here, the focus is on sliding wear. A wear model based on Archard's equation is employed to predict wear depth. The pressure angle and the tip relief are parameterized. In the analysis, instantaneous contact loads and Hertz pressures are used in wear depth calculations. It is shown that as the amount of the tip relief increases, the wear depth, particularly at the beginning and end of the mesh, decreases. As the number of wear cycles increases, the effect of the tip relief modification on wear depths decreases slightly. It was also shown that with an increase in tip relief, the dynamic load decreases. However, if the amount of tip relief modification increases excessively, the maximum dynamic load also increases. Therefore, an excessive increase in tip relief modification should be avoided, whereby the level of excessive increase depends on the tip relief configuration.