Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension.

Sag, Saim; Yeşilbursa, DİLEK; Gullulu, NAZMİYE

doi:10.5152/tjg.2014.7688

Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.25, ss.429-32, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25
Basım Tarihi: 2014
Doi Numarası: 10.5152/tjg.2014.7688
Dergi Adı: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.429-32
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Pulmonary arterial hypertension (PAH) that occurs in the setting of cirrhosis and portal hypertension is referred to as portopulmonary hypertension (PPHTN). Liver transplantation (LTx) is curative, but the presence of moderate-to-severe PPHTN may be a contraindication for transplantation because of the elevated risk of peri-and post-transplantation morbidity and mortality. We report a successful liver transplantation in a patient with liver cirrhosis after treatment of moderate-to-severe PPHTN with a combination of the dual endothelin receptor antagonist bosentan and the specific phosphodiesterase-5 inhibitor sildenafil.