Effects of cross-linked high-molecular-weight hyaluronic acid on epidural fibrosis: experimental study

Isik S., TAŞKAPILIOĞLU M. Ö., ÖZ ATALAY F., DOĞAN Ş.

JOURNAL OF NEUROSURGERY-SPINE, cilt.22, sa.1, ss.94-100, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3171/2014.10.spine131147
  • Dergi Adı: JOURNAL OF NEUROSURGERY-SPINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-100
  • Anahtar Kelimeler: cross-linked high-molecular-weight hyaluronic acid, epidural fibrosis, laminectomy, LAMINECTOMY SCAR FORMATION, PERIDURAL FIBROSIS, RAT MODEL, EXPANDED POLYTETRAFLUOROETHYLENE, LUMBAR LAMINECTOMY, PREVENTION, MEMBRANE, DISKECTOMY, ADHESION, INHIBITION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

OBJECT Epidural fibrosis is nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in the intimate vicinity of and around the origin of the radicular sheath. The formation of dense fibrous tissue causes lumbar and radicular pain. In addition to radicular symptoms, the formation of scar tissue may cause problems during reoperation. The authors aimed to investigate the effects of cross-linked high-molecular-weight hyaluronic acid (HA), an HA derivative known as HA gel, on the prevention of epidural fibrosis by using histopathological and biochemical parameters.