Effects of cross-linked high-molecular-weight hyaluronic acid on epidural fibrosis: experimental study

Isik S., TAŞKAPILIOĞLU M. Ö., ÖZ ATALAY F., DOĞAN Ş.

JOURNAL OF NEUROSURGERY-SPINE, vol.22, no.1, pp.94-100, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.3171/2014.10.spine131147
  • Journal Name: JOURNAL OF NEUROSURGERY-SPINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.94-100
  • Keywords: cross-linked high-molecular-weight hyaluronic acid, epidural fibrosis, laminectomy, LAMINECTOMY SCAR FORMATION, PERIDURAL FIBROSIS, RAT MODEL, EXPANDED POLYTETRAFLUOROETHYLENE, LUMBAR LAMINECTOMY, PREVENTION, MEMBRANE, DISKECTOMY, ADHESION, INHIBITION
  • Bursa Uludag University Affiliated: Yes

Abstract

OBJECT Epidural fibrosis is nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in the intimate vicinity of and around the origin of the radicular sheath. The formation of dense fibrous tissue causes lumbar and radicular pain. In addition to radicular symptoms, the formation of scar tissue may cause problems during reoperation. The authors aimed to investigate the effects of cross-linked high-molecular-weight hyaluronic acid (HA), an HA derivative known as HA gel, on the prevention of epidural fibrosis by using histopathological and biochemical parameters.