Increased Serum Hepcidin Levels in Brucellosis

YILMAZ E. , Ayarci A. O. , SIĞIRLI D. , Torlar M. O. , BUDAK F. , Goral G., ...More

CLINICAL LABORATORY, vol.60, no.11, pp.1837-1843, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.7754/clin.lab.2014.131209
  • Title of Journal : CLINICAL LABORATORY
  • Page Numbers: pp.1837-1843


Background: Both CD4(+) and CD8(+) T lymphocytes play crucial roles in immunity to Brucella, in part because they secrete interferon (IFN)-gamma and activate the bactericidal functions in macrophages. Hepcidin is an antimicrobial and iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron. Recent studies suggest that circulating monocytes and resident liver macrophages may influence both basal and inflammatory expression of hepcidin and these two cell types act in concert to regulate hepcidin production during inflammation. Here, we aimed to investigate the association of hepcidin levels with Brucellosis.