The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome


Selimoglu H., Duran C., Kiyici S., Ersoy C., Guclu M., ÖZKAYA G. , ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.33, no.4, pp.234-238, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1007/bf03345785
  • Title of Journal : JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Page Numbers: pp.234-238
  • Keywords: Insulin resistance, polycystic ovary syndrome, vitamin D, glucose metabolism, androgen, LONG-TERM TREATMENT, GLUCOSE-TOLERANCE, HYPOVITAMINOSIS-D, OBESE WOMEN, SENSITIVITY, SECRETION, 1,25-DIHYDROXYVITAMIN-D3, PREVALENCE, RECEPTOR, TESTOSTERONE

Abstract

Insulin resistance (IR) is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of IR and glucose metabolism. Aim of this study was aimed to determine the effect of vitamin D replacement therapy on glucose metabolism, insulin, and androgen levels in obese, insulin-resistant women with PCOS. Eleven women with PCOS were included in the study. Mean age of the patients was 23.6+/-5.7 yr, body mass index 33.9+/-5.1 kg/m(2). Six patients (54.5%) had acantosis nigricans and 10 (90.9%) oligoamenorrhea. The mean Ferriman Gallwey score was 14.1+/-4.6. Only 2 women were within the normal limits of vitamin D levels as >20 ng/ml. Three weeks after the administration of the single dose of 300,000 units of vitamin D3 orally, 25-hydroxyvitamin D3 significantly increased from 16.9+/-16 ng/ml to 37.1+/-14.6 ng/ml (p: 0.027) and only 2 women were detected to have vitamin D3 levels <20 ng/ml. Although glucose and insulin levels were decreased non-significantly, homeostasis model assesment (HOMA)-IR significantly decreased from 4.41+/-1.38 to 3.67+/-1.48 (p: 0.043). No significant alterations were witnessed at the levels of DHEAS, total and free testosterone, androstenedione. No correlation was found between vitamin D with HOMA and other hormonal parameters. In conclusion, women with PCOS have mostly insufficient vitamin D levels, and vitamin D replacement therapy may have a benefical effect on IR in obese women with PCOS. (J. Endocrinol. Invest. 33: 234-238, 2010) (C) 2010, Editrice Kurtis