Akademik Veri Yönetim Sistemi
26th International EVSSAR European Veterinary Society For Small Animal Reproduction Congress, Porto, Portekiz, 3 - 06 Temmuz 2025, cilt.60, ss.1-120, (Özet Bildiri)
Ovarian Remnant Syndrome (ORS) is a complex condition that
can present with various clinical signs include vocalization, lordosis,
attraction of male animals, and even allowing mating.
The use of Anti-Müllerian
Hormone (AMH), widely regarded as
the most reliable marker of human ovarian reserve (1), is a current
area of interest as a diagnostic biomarker for ORS in pets.
However, previous studies with limited sample sizes have not
reached a consensus on its diagnostic accuracy (2,3) or established
a definitive threshold value (4). Additionally, the relationship
with AMH and Antral Follicle Count (AFC) is limited to a
single study (5) consisting of intact cats. Thus, it is anticipated
that performing AFC alongside AMH measurement will provide
valuable insights into the diagnosis and clinical course of
ORS in cats.
This study involved 25 female cats diagnosed with ORS and the
methodology included examination of the reproductive tract,
blood sampling for serum AMH measurement (ECLIA method)
(6), surgical intervention to remove OR, histopathological examination,
and AFC determination of OR. The statistical analysis
employed descriptive measures such as mean and percentage,
along with the Pearson correlation test to assess relationships
between variables.
The mean serum AMH level was found to be 0.975 ± 0.22 ng/mL
(range 0.02–4.71) in 25 cats in which ORS was confirmed postoperatively.
The previous surgical site selections resulting in ORS
were found to be similar, with 52% being lateral and 48% median
laparotomy. The clinical findings of ORS appeared on average
128.5 ± 25.9 days (range 7–390) after the surgery. In all cases, lordosis
and rolling were consistently observed as the common signs
of estrus behavior. One particular case #10, with an ovarian remnant
volume of 0.1 ml and a serum AMH level of 0.13 ng/mL, was
found to have even allowed mating. The mean volume of the OR
was 0.19 ±0.02 ml (ranged 0.02-0.50).
It was noticed that a majority
of the OR's (78%) contained follicular cysts. While no correlation
between AMH and AFC was detected, a negative correlation
(p < 0.017) of AMH with follicular cysts was identified.
This study is the first to assess AFC with remnant volume, and
their relationship with AMH in cats with ORS, using the largest
sample size in feline ORS literature. While no direct association
was found between AMH levels and ovarian remnant volume or
the severity of clinical signs, follicular cysts were linked to decreased
AMH concentrations. In addition, it was found that the
mating behavior was unrelated to the remaining ovarian tissue
or serum AMH levels.
This study was a PhD Thesis Project supported by the Bursa
Uludag University, Scientific Research Projects Unit.
References:
1) Bedenk et al., J Assist Reprod Genet 2020;37(1):89-100.
2) Gozer et al., Theriogenology 2023;200:106-113.
3) Flock et al., J Feline Med Surg 2022;1098612X221099195
4) Place et al., J Vet Diagn 2011;23(3):524e7. 5)Lapuente et al.,
Theriogenology 2023;197:111-115.
6)Snoeck et al., Reprod
Domest 2017;52:98-102.