SERUM CANCER FROM LUNG-6: PROMISING BIOMARKER TO DIFFERENTIATE CPFE FROM IPF
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, cilt.39, sa.4, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.36141/svdld.v39i4.11344
- Dergi Adı: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Anahtar Kelimeler: Combined pulmonary fibrosis emphysema, Idiopathic pulmonary fibrosis, Krebs von den Lungen-6, Surfactant protein-A, Surfactant protein-D, Pulmonary function tests, Echocardiography, IDIOPATHIC PULMONARY-FIBROSIS, SURFACTANT PROTEIN-A, QUALITY-OF-LIFE, CIRCULATING KL-6, EMPHYSEMA, HYPERTENSION, MARKERS
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Background: Combined pulmonary fibrosis and emphysema (CPFE) has been recognised as a phe-notype of pulmonary fibrosis. We aimed to compare serum surfactant protein-A (SP-A), surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6) levels, functional parameters, in CPFE and IPF (idiopathic pul-monary fibrosis) patients. Methods: Patients diagnosed with ???CPFE??? and ???IPF??? were consecutively included in 6 months as two groups. The patients with connective tissue diseases are excluded. Results: In this study, 47 patients (41 males, 6 females) with CPFE (n = 21) and IPF (n = 26) with a mean age of 70.12 ?? 8.75 were evaluated. CPFE patients were older, had more intense smoking history, had lower DLCO/VA, lower FVC, and worse six-minute walking distance than the IPF group (p=0.005, p=0.027, p=0.02, p<0.001, p=0.001, respec-tively). Serum KL-6 levels were higher in CPFE group compared to IPF group [264.70 U/ml (228.90-786) vs 233.60 (101.8-425.4), p<0.001]. Serum KL-6 levels of 245.4 U/ml and higher have 81% sensitivity and 73% specificity for the discrimination of CPFE from IPF. Conclusions: Our study has shown that serum KL-6 level is a promising biomarker to differentiate CPFE from IPF. In CPFE cases respiratory and functional parameters are worse than those of pure fibrosis cases.