Role of epigenetics in carcinogenesis: Recent advancements in anticancer therapy

Hussain S., Tulsyan S., Dar S. A., Sisodiya S., Abiha U., Kumar R., ...More

SEMINARS IN CANCER BIOLOGY, vol.83, pp.441-451, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2022
  • Doi Number: 10.1016/j.semcancer.2021.06.023
  • Journal Name: SEMINARS IN CANCER BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.441-451
  • Keywords: Epigenetics, DNA methylation, Histone modification, Non-coding RNAs, Epigenetic biomarkers, Precision medicine, Nanomedicine, ABERRANT PROMOTER METHYLATION, SMALL NONCODING RNA, DNA METHYLATION, CELL-PROLIFERATION, GENE-EXPRESSION, HUMAN CANCER, MICRORNA, BREAST, PROSTATE, INHIBITION
  • Bursa Uludag University Affiliated: No

Abstract

The role of epigenetics in the etiology of cancer progression is being emphasized for the past two decades to check the impact of chromatin modifiers and remodelers. Histone modifications, DNA methylation, chromatin remodeling, nucleosome positioning, regulation by non-coding RNAs and precisely microRNAs are influential epigenetic marks in the field of progressive cancer sub-types. Furthermore, constant epigenetic changes due to hyper or hypomethylation could efficiently serve as effective biomarkers of cancer diagnosis and therapeutic development. Ongoing research in the field of epigenetics has resulted in the resolutory role of various epigenetic markers and their inhibition using specific inhibitors to arrest their key cellular functions in in-vitro and preclinical studies. Although, the mechanism of epigenetics in cancer largely remains unexplored. Nevertheless, various advancements in the field of epigenetics have been made through transcriptome analysis and in-vitro genome targeting technologies to unravel the applicability of epigenetic markers for future cancer therapeutics and management. Therefore, this review emphasizes on recent advances in epigenetic landscapes that could be targeted/explored using novel approaches as personalized treatment modalities for cancer containment.