Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents

Millot F., Dupraz C., Guilhot J., Suttorp M., Brizard F., Leblanc T., ...More

CANCER, vol.123, no.18, pp.3609-3616, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 18
  • Publication Date: 2017
  • Doi Number: 10.1002/cncr.30767
  • Journal Name: CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3609-3616
  • Bursa Uludag University Affiliated: Yes

Abstract

BACKGROUNDIn the adult population with newly diagnosed chronic myeloid leukemia (CML), variant translocations are usually not considered to be impairing the prognosis, whereas some additional cytogenetic abnormalities (ACAs) are associated with a negative impact on survival. Because of the rarity of CML in the pediatric population, such abnormalities have not been investigated in a large group of children with CML.