Low serum IGF-1 and increased cytokine levels in tracheal aspirate samples are associated with bronchopulmonary dysplasia


Yilmaz C., Koksal N., ÖZKAN H., Dorum B. A. , Bagci O.

TURKISH JOURNAL OF PEDIATRICS, vol.59, no.2, pp.122-129, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.24953/turkjped.2017.02.003
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.122-129
  • Keywords: bronchopulmonary dysplasia, cytokines, IGF-1, premature, tracheal aspirate fluid, CHRONIC LUNG-DISEASE, BIRTH-WEIGHT INFANTS, RESPIRATORY-DISTRESS-SYNDROME, BRONCHOALVEOLAR LAVAGE FLUID, NECROSIS-FACTOR-ALPHA, GROWTH-FACTOR-I, PREMATURE-INFANTS, PRETERM INFANTS, IL-8 EXPRESSION, COMPLICATIONS

Abstract

Despite developments in the perinatal and neonatal care, bronchopulmonary dysplasia (BPD) is still the most frequently seen long-term complication in preterm infants. The aim of this prospective study is to investigate the association between the development of BPD and serial measurements of IGF-1 levels and their relationship with levels of IGF-1 and cytokine in tracheal aspirate fluids. A total of 40 premature infants, born at a gestational age of <= 32 weeks, were enrolled in the study. On postnatal day-1, 3, 7, 21 and 28 serum IGF-1 levels and IGF-1 levels, IL-6, IL-8, IL-10 and TNF-alpha levels in tracheal aspirate fluid samples of intubated cases were examined. Mean gestational age of 40 patients included in the study was 29.41 +/- 2.23 weeks, and their mean birth weight was 1,256.85 +/- 311.48 g. BPD was detected in 35% of cases. Mean gestational week and birth weight of the cases that developed BPD were 30 +/- 3 weeks and 1,150 +/- 295 g, respectively. Serum IGF-1 levels on postnatal day-1, 3, 7, 21 and 28 in cases who developed BPD were significantly lower when compared with those without BPD (p<0.01). Levels of IL-6, IL-8, IL-10, and TNF-alpha in tracheal aspirate samples were significantly higher in cases with BPD compared to those without BPD (p<0.05). IGF-1 levels in tracheal aspirate fluid samples did not differ significantly based on the presence of BPD (p>0.05). Severity of BPD was associated with decreased serum IGF-1 levels and increased cytokine levels in tracheal aspirate samples.