Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C


Altunok E. S. , SAYAN M., AKHAN S., AYGEN B., YILDIZ O., Koruk S. T. , ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.50, pp.1-5, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ijid.2016.07.003
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1-5

Abstract

Background: Drug resistance development is an expected problem during treatment with protease inhibitors (PIs), this is largely due to the fact that Pls are low-genetic barrier drugs. Resistance-associated variants (RAVs) however may also occur naturally, and prior to treatment with Pls, the clinical impact of this basal resistance remains unknown. In Turkey, there is yet to be an investigation into the hepatitis C (HCV) drug associated resistance to oral antivirals.