Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells - An immuno electron microscopic study


Seftalioglu A., Karakus S., Dundar S., Can B., Erdemli E., Irmak M., ...More

ACTA ONCOLOGICA, vol.42, no.1, pp.71-74, 2003 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1080/0891060310002267
  • Journal Name: ACTA ONCOLOGICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.71-74

Abstract

Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.