Investigation of Neuroprotective Effects of Cyclooxygenase Inhibitors in the 6-Hydroxydopamine Induced Rat Parkinson Model

Gören B., Mimbay Z., Bilici N., Zarifoğlu M., Ogul E., Korfali E.

TURKISH NEUROSURGERY, cilt.19, ss.230-236, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.230-236
  • Anahtar Kelimeler: 6-OHDA, NSAID, Parkinson model, Rat, INDUCED DOPAMINERGIC NEUROTOXICITY, IN-VIVO MICRODIALYSIS, MPTP-MOUSE MODEL, NF-KAPPA-B, SODIUM-SALICYLATE, ANTIINFLAMMATORY DRUGS, 7-NITROINDAZOLE PROTECTS, INDUCED DEGENERATION, DISEASE, ASPIRIN
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

AIM: Recent experimental and clinical studies on Parkinson's disease point out the pivotal role of inflammation in the pathogenesis of neurodegeneration and the possible positive effects of nonsteroidal anti-inflammatory drug therapies. Our aim in this study was to investigate the preventive effects of nonsteroidal anti-inflammatory drugs in the 6-hydroxydopamine (6-OHDA) induced rat model of Parkinson's disease.