Investigation of Neuroprotective Effects of Cyclooxygenase Inhibitors in the 6-Hydroxydopamine Induced Rat Parkinson Model

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Gören B., Mimbay Z., Bilici N., Zarifoğlu M., Ogul E., Korfali E.

TURKISH NEUROSURGERY, vol.19, pp.230-236, 2009 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 19
• Publication Date: 2009
• Journal Name: TURKISH NEUROSURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.230-236
• Keywords: 6-OHDA, NSAID, Parkinson model, Rat, INDUCED DOPAMINERGIC NEUROTOXICITY, IN-VIVO MICRODIALYSIS, MPTP-MOUSE MODEL, NF-KAPPA-B, SODIUM-SALICYLATE, ANTIINFLAMMATORY DRUGS, 7-NITROINDAZOLE PROTECTS, INDUCED DEGENERATION, DISEASE, ASPIRIN
• Bursa Uludag University Affiliated: Yes

Abstract

AIM: Recent experimental and clinical studies on Parkinson's disease point out the pivotal role of inflammation in the pathogenesis of neurodegeneration and the possible positive effects of nonsteroidal anti-inflammatory drug therapies. Our aim in this study was to investigate the preventive effects of nonsteroidal anti-inflammatory drugs in the 6-hydroxydopamine (6-OHDA) induced rat model of Parkinson's disease.