Atıf İçin Kopyala
Pat Y., Yazici D., D'avino P., Li M., Ardıçlı S., Ardicli O., ...Daha Fazla
INTERNATIONAL IMMUNOLOGY, ss.1-28, 2024 (SCI-Expanded)
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Yayın Türü:
Makale / Derleme
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Basım Tarihi:
2024
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Doi Numarası:
10.1093/intimm/dxae002
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Dergi Adı:
INTERNATIONAL IMMUNOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
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Sayfa Sayıları:
ss.1-28
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Bursa Uludağ Üniversitesi Adresli:
Evet
Özet
Abstract
The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting the epithelial barrier. Global pollution and environmental toxic agent exposure have worsened over six decades because of uncontrolled growth, modernisation, and industrialisation, affecting human health. Introducing new chemicals without any reasonable control of their health effects through these years has led to documented adverse effects, especially on the skin and mucosal epithelial barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- and nano-plastics, diesel exhaust, cigarette smoke and ozone, have been shown to compromise the epithelial barrier integrity. This disruption is linked to the opening of the tight junction barriers, inflammation, cell death, oxidative stress and metabolic regulation. Consideration must be given to the interplay of toxic substances, underlying inflammatory diseases, and medications, especially in affected tissues. This review article discusses the detrimental effect of environmental barrier-damaging compounds on human health and involves cellular and molecular mechanisms.