AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients.

Eminler A. T. , Ayyıldız T., Irak K., Kıyıcı M. , Gürel S. , Dolar E. , ...More

European journal of gastroenterology & hepatology, vol.27, pp.1361-6, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2015
  • Doi Number: 10.1097/meg.0000000000000468
  • Title of Journal : European journal of gastroenterology & hepatology
  • Page Numbers: pp.1361-6


Background and aim Noninvasive tests are primarily used for staging hepatic fibrosis in patients with chronic liver disease. In clinical practice, serum aminotransferase levels, coagulation parameters, and platelet count have been used to predict whether or not a patient has cirrhosis. In addition, several studies have evaluated the accuracy of combinations (or ratios) of these measures. The present study aimed to investigate the relationship between five noninvasive models [AST/ALT ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), age-platelet index (APind), and King's score] and the degree of hepatic fibrosis as determined by biopsy in patients with chronic hepatitis B and C.