A short synthesis of (S)-2-(diphenylmethyl)pyrrolidine, a chiral solvating agent for NMR analysis
TETRAHEDRON-ASYMMETRY, cilt.8, sa.1, ss.149-153, 1997 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 1997
- Doi Numarası: 10.1016/s0957-4166(96)00495-8
- Dergi Adı: TETRAHEDRON-ASYMMETRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.149-153
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
A three step synthesis of (S)-2(diphenylmethyl)pyrrolidine 4 is described which allows its preparation on a large scale. The C-2 symmetric diamines 5 and 6 have been prepared from 4 and are attractive as potential ligands for asymmetric transformations. Pyrrolidine 4 has been assessed as a chiral solvating agent for the NMR analysis of chiral compounds. It emerges as a good CSA for carboxylic acids and some secondary alcohols. (C) 1997, Elsevier Science Ltd. All rights reserved.