Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, no.1, pp.132-138, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Publication Date: 2017
- Doi Number: 10.1515/cclm-2016-0005
- Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.132-138
- Keywords: contrast induced nephropathy, HDL-cholesterol, monocyte, PERCUTANEOUS CORONARY INTERVENTION, ACUTE KIDNEY INJURY, HIGH-DENSITY-LIPOPROTEIN, ELEVATION MYOCARDIAL-INFARCTION, CREATININE CLEARANCE RATIO, PRIMARY ANGIOPLASTY, CARDIOVASCULAR EVENTS, N-ACETYLCYSTEINE, RENAL-FUNCTION, RISK SCORE
- Bursa Uludag University Affiliated: Yes
Abstract
Background: Contrast induced nephropathy (CIN) has been proven to be a clinical condition related to adverse cardiovascular outcomes. In recent studies, the monocyte to high density lipoprotein ratio (MHR) has been-postulated as a novel parameter associated with adverse renal and cardiovascular outcomes. In this study we-investigated the association of MHR with CIN in-ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Methods: Consecutive STEMI patients treated with primary PCI were prospectively recruited. Subjects were categorized into two groups; as patients who developed CIN (CIN+) and patients who did not develop CIN (CIN-) during hospitalization. CIN was defined as either a 25% increase in serum creatinine from baseline or 44.20 mu mol/L increase in absolute value, within 72 h of intravenous contrast administration. Results: A total number of 209 patients were included in the study. Thirty-two patients developed CIN (15.3%). In the CIN (+) patients, monocytes were higher [1.02 (0.83-1.39) vs. 0.69 (0.53-0.90) 109/L, p < 0.01] and HDL cholesterol levels were lower [0.88 (0.78-1.01) vs. 0.98 (0.88-1.14) mmol/L, p < 0.01]. In addition, MHR was significantly higher in the CIN (+) group [1.16 (0.89-2.16) vs. 0.72 (0.53-0.95) 10(9)/mmol, p < 0.01]. In multivariate logistic regression analysis, MHR, Mehran score, AGEF score and CV/eGFR were independently correlated with CIN. Conclusions: Higher MHR levels may predict CIN development after primary PCI in STEMI patients.