Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis

Kahvecioglu S., Dilek K., Akdag I., Gullulu M., Demircan C., Ersoy A., ...More

NEPHROLOGY, vol.11, no.3, pp.232-237, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1797.2006.00562.x
  • Journal Name: NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-237
  • Keywords: amyloidosis, celecoxib, cyclooxygenase-2, non-steroidal anti-inflammatory drugs, proteinuria, rofecoxib, GASTROINTESTINAL TOXICITY, CARDIOVASCULAR EVENTS, RHEUMATOID-ARTHRITIS, NEPHROTIC SYNDROME, COX-2 INHIBITORS, ROFECOXIB, RESOLUTION, CELECOXIB, NAPROXEN, RISK
  • Bursa Uludag University Affiliated: Yes

Abstract

Aims: Because the cardiovascular system (CVS) side-effects of cyclooxygenase-2 (COX-2) selective inhibitors have recently been questioned, we aimed to compare the renal and haemodynamic effects of cyclooxygenase selective (celecoxib and rofecoxib) and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin) in patients with renal amyloidosis secondary to rheumatological diseases who required anti-inflammatory agents and are taking maximum tolerable dose of angiotensin-converting enzyme inhibitors.