Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B

Bonino F., Marcellin P., Lau G. K. K. , Hadziyannis S., Jin R., Piratvisuth T., ...More

GUT, vol.56, no.5, pp.699-705, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1136/gut.2005.089722
  • Title of Journal : GUT
  • Page Numbers: pp.699-705


Objective: In a trial of patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, 24 week post-treatment biochemical and virological response rates with peginterferon alpha-2a with or without lamivudine were significantly higher than with lamivudine alone. The effect of pre-treatment factors on post-treatment responses was investigated.