Association and Prognostic Significance of the Functional-1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer

Avci N., Ture M., DELİGÖNÜL A., Cubukcu E., Olmez O. F., ŞAHİNTÜRK S., ...More

PATHOLOGY & ONCOLOGY RESEARCH, vol.21, no.4, pp.1243-1247, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1007/s12253-015-9950-7
  • Journal Name: PATHOLOGY & ONCOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1243-1247
  • Keywords: Gastric cancer, Matrix metalloproteinases, Polymorphism, Association study, Prognosis, MATRIX METALLOPROTEINASES, MATRIX-METALLOPROTEINASE-9, EPIDEMIOLOGY, GENE, METAANALYSIS, RISK
  • Bursa Uludag University Affiliated: Yes

Abstract

Matrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case-control design the association between the functional -1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case-control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 -1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44-1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40-1.94, P = 0.84). When the MMP-9 -1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 -1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects.