Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever

Dundaroz R., Ulucan H., Denli M., Karapinar K., Aydin H., Baltaci V.

PEDIATRICS INTERNATIONAL, vol.43, no.3, pp.276-280, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1046/j.1442-200x.2001.01397.x
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.276-280
  • Bursa Uludag University Affiliated: No

Abstract

Backround: Benzathine penicillin is the most widely used antibiotic in the prophylaxis of children with rheumatic fever. The aim of the present study was to evaluate the DNA damage in children receiving one dose of 1.2 million units benzathine penicillin every 4 weeks over a long period to prevent recurrences of rheumatic fever.