Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.55, sa.7, ss.1657-1663, 2025 (SCI-Expanded, Scopus, TRDizin)
Background/aim: There is increasing interest in endocrine disrupting chemicals because of the potential effects on neurological health. These chemicals are widely found in various consumer products and industrial processes, and can lead to serious disorders of the endocrine system by disrupting hormone synthesis, expression, and function. The aim of this review was to examine epidemiological and experimental findings by investigating the link between exposure to endocrine disrupting chemicals and adverse neurological outcomes. Materials and methods: In the preparation of this review, a PubMed literature search was conducted using the words “endocrine disruptors,” “neuroendocrine effects,” “neurobehavioral effects,” and “neurodevelopmental effects” and articles containing relevant studies were examined. Results: Recent studies have shown a strong correlation between exposure to endocrine disrupting chemicals and the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, and neurodevelopmental diseases such as autism spectrum disorder and attention deficit hyperactivity disorder. The effects of common pollutants such as pesticides, bisphenol A, polychlorinated biphenyls, and heavy metals on the endocrine system have been especially emphasized. Conclusion: In conclusion, understanding the role played by endocrine disrupting chemicals in the development of neurological diseases will be of critical importance in the development of new strategies to prevent these diseases.
Key words: Endocrine disruptors, neurological diseases, Parkinson’s disease, Alzheimer’s disease, neuroendocrine effects, neurobehavioral and neurodevelopmental effects