The Effect of Alkalinized Bupivacaine in Infraclavicular Brachial Plexus Blockade I̊nfraklaviküler Brakiyal Pleksus Blokajinda Alkalinize Bupivakainin Etkisi

Moǧol E. B., TÜRKER Y. G., Özkan U., Uçkunkaya N., Şahin Ş.

Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, vol.31, no.7, pp.353-357, 2003 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 7
  • Publication Date: 2003
  • Journal Name: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.353-357
  • Keywords: Brachial plexus block, Bupivacaine, Sodium bicarbonate
  • Bursa Uludag University Affiliated: Yes


The aim of the current study is to determine the effects of alkalinized bupivacaine 0.25% on the time of onset of sensory and motor blockade and duration of postoperative analgesia during infraclavicular brachial plexus blockade. In this double-blind study, fifty ASA physical status I ve II patients were randomly allocated into two groups. Group 1 (n=25) received 30 mL of bupivacaine 0.25% (pH=6.6), while Group 2 (n=25) received 30 mL of alkalinized bupivacaine 0.25% (pH=7.4). The onset of sensory and motor blockade was significantly shorter in Group 2 (p<0.0001). The duration of postoperative analgesia was found to be significantly longer in Group 2 (p<0.0001). As a conclusion; the alkalinization of bupivacaine 0.25% solution provides clinical advantage in infraclavicular brachial plexus blockade when compared with commercially available bupivacaine.