The Effect of Alkalinized Bupivacaine in Infraclavicular Brachial Plexus Blockade I̊nfraklaviküler Brakiyal Pleksus Blokajinda Alkalinize Bupivakainin Etkisi

Moǧol E. B. , TÜRKER Y. G. , Özkan U., Uçkunkaya N., Şahin Ş.

Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, vol.31, no.7, pp.353-357, 2003 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 7
  • Publication Date: 2003
  • Journal Name: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.353-357
  • Keywords: Brachial plexus block, Bupivacaine, Sodium bicarbonate


The aim of the current study is to determine the effects of alkalinized bupivacaine 0.25% on the time of onset of sensory and motor blockade and duration of postoperative analgesia during infraclavicular brachial plexus blockade. In this double-blind study, fifty ASA physical status I ve II patients were randomly allocated into two groups. Group 1 (n=25) received 30 mL of bupivacaine 0.25% (pH=6.6), while Group 2 (n=25) received 30 mL of alkalinized bupivacaine 0.25% (pH=7.4). The onset of sensory and motor blockade was significantly shorter in Group 2 (p<0.0001). The duration of postoperative analgesia was found to be significantly longer in Group 2 (p<0.0001). As a conclusion; the alkalinization of bupivacaine 0.25% solution provides clinical advantage in infraclavicular brachial plexus blockade when compared with commercially available bupivacaine.