Immunoglobulin Deficiencies: The B-Lymphocyte Side of DiGeorge Syndrome

Patel, Kiran; Akhter, Javeed; Kobrynski, Lisa; Gathman, Benjamin; Davis, Onika; Sullivan, SARA

doi:10.1016/j.jpeds.2012.06.018

Immunoglobulin Deficiencies: The B-Lymphocyte Side of DiGeorge Syndrome

Patel K., Akhter J., Kobrynski L., Gathman B., Davis O., Sullivan K. E.

JOURNAL OF PEDIATRICS, cilt.161, sa.5, ss.950-954, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 161 Sayı: 5
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.jpeds.2012.06.018
Dergi Adı: JOURNAL OF PEDIATRICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.950-954
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency. (J Pediatr 2012;161:950-3).