Immunoglobulin Deficiencies: The B-Lymphocyte Side of DiGeorge Syndrome

Patel K., Akhter J., Kobrynski L., Gathman B., Davis O., Sullivan K. E.

JOURNAL OF PEDIATRICS, vol.161, no.5, pp.950-954, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 161 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jpeds.2012.06.018
  • Journal Name: JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.950-954
  • Bursa Uludag University Affiliated: Yes

Abstract

DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency. (J Pediatr 2012;161:950-3).