From drug eluting stents to bioresorbable scaffolds; to new horizons in PCI


Tenekecioglu E., Bourantas C., Abdelghani M., Zeng Y., Silva R. C. , Tateishi H., ...More

EXPERT REVIEW OF MEDICAL DEVICES, vol.13, no.3, pp.271-286, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1586/17434440.2016.1143356
  • Title of Journal : EXPERT REVIEW OF MEDICAL DEVICES
  • Page Numbers: pp.271-286

Abstract

Drug eluting stents and particularly the fully bioresorbable drug-eluting scaffolds herald a new era in percutaneous treatment of coronary artery disease. There has been tremendous progress in drug eluting stents with fully biodegradable coating polymers and polymer-free devices with reservoir technology planting the anti-proliferative drug. Despite significant decreases in in-stent restenosis rates with drug eluting stents, limitations still remain before we are able to develop fully bioresorbable scaffolds. Enhanced mechanical flexibility that provides superior conformability to the vessel wall, resumption of the vasoreactivity in the follow-up period and improving visualization on non-invasive imaging modalities are some of the supremacies of the fully bioresorbable scaffolds. In this review, we aim to give a general view on the latest developments in metallic drug eluting stents and fully bioresorbable scaffolds.