The effect of centrally injected CDP-choline on respiratory system; involvement of phospholipase to thromboxane signaling pathway
Respiratory Physiology and Neurobiology, cilt.195, sa.1, ss.50-58, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 195 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.1016/j.resp.2014.02.005
- Dergi Adı: Respiratory Physiology and Neurobiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.50-58
- Anahtar Kelimeler: CDP-choline, Intracerebroventricular, Respiratory frequency, Tidal volume, Minute ventilation, Central prostaglandinergic system, Central cholinergic receptors, INCREASES PLASMA VASOPRESSIN, ARACHIDONIC-ACID, BRAIN, RAT, PRESSOR, ACTIVATION, A(2), HYPOTENSION, CYTIDINE, RECEPTOR
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Exogenous administration of CDP-choline has been shown to affect brain metabolism and to exhibit cardiovascular, neuroendocrine neuroprotective actions. On the other hand, little is known regarding its respiratory actions and/or central mechanism of its respiratory effect. Therefore the current study was designed to investigate the possible effects of centrally injected CDP-choline on respiratory system and the mediation of the central cholinergic receptors and phospholipase to thromboxane signaling pathway on CDP-choline-induced respiratory effects in anaesthetized rats.Intracerebroventricularly (i.c.v.) administration of CDP-choline induced dose- and time-dependent increased respiratory rates, tidal volume and minute ventilation of male anaesthetized Spraque Dawley rats. İ.c.v. pretreatment with atropine failed to alter the hyperventilation responses to CDP-choline whereas mecamylamine, cholinergic nicotinic receptor antagonist, mepacrine, phospholipase A2 inhibitor, and neomycin phospholipase C inhibitor, blocked completely the hyperventilation induced by CDP-choline. In addition, central pretreatment with furegrelate, thromboxane A2 synthesis inhibitor, also partially blocked CDP-choline-evoked hyperventilation effects.These data show that centrally administered CDP-choline induces hyperventilation which is mediated by activation of central nicotinic receptors and phospholipase to thromboxane signaling pathway. © 2014 Elsevier B.V.