Treatment of traumatic brain injury with 17 alpha-ethinylestradiol-3-sulfate in a rat model


Kim H., Yu T., Cam-Etoz B., van Groen T., Hubbard W. J. , Chaudry I. H.

JOURNAL OF NEUROSURGERY, vol.127, no.1, pp.23-31, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 127 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3171/2016.7.jns161263
  • Journal Name: JOURNAL OF NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.23-31
  • Bursa Uludag University Affiliated: Yes

Abstract

OBJECTIVE 17 alpha-ethynylestradiol-3-sulfate (EE-3-SO4) is a highly water-soluble synthetic estrogen that has an extended half-life (10 hours) over that of naturally occurring estrogen (similar to 10 minutes). In this study, EE-3-SO4 was evaluated in a lateral fluid percussion induced traumatic brain injury (TBI) model in rats.