Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells

Aydinlik S., Dere E., Ulukaya E.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1863, pp.903-916, 2019 (SCI-Expanded) identifier identifier identifier


Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces autophagy in cancer cells. This study aimed to investigate whether EGFR inhibition by canertinib induces autophagy and this induction influence the effect of Palladium (Pd) (II) complex and 5-fluorouracil (5-FU) especially in nontoxic doses.