Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells

Aydinlik, Seyma; Dere, EGEMEN; Ulukaya, Engin

doi:10.1016/j.bbagen.2019.02.014

Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells

Aydinlik S., Dere E., Ulukaya E.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1863, ss.903-916, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1863
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.bbagen.2019.02.014
Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.903-916
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces autophagy in cancer cells. This study aimed to investigate whether EGFR inhibition by canertinib induces autophagy and this induction influence the effect of Palladium (Pd) (II) complex and 5-fluorouracil (5-FU) especially in nontoxic doses.