Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells


Aydinlik S., Dere E. , Ulukaya E.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1863, pp.903-916, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1863
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bbagen.2019.02.014
  • Title of Journal : BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Page Numbers: pp.903-916

Abstract

Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces autophagy in cancer cells. This study aimed to investigate whether EGFR inhibition by canertinib induces autophagy and this induction influence the effect of Palladium (Pd) (II) complex and 5-fluorouracil (5-FU) especially in nontoxic doses.