Antioxidative effects of uridine in a neonatal rat model of hyperoxic brain injury

Al N., Çakir A., Koç C., Cansev M., Alkan T.

Turkish journal of medical sciences, vol.50, pp.2059-2066, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2002-14
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2059-2066
  • Keywords: Uridine, hyperoxia, antioxidative, neonatal rat, DJ-1, OXIDATIVE STRESS, CELL-DEATH, DEVELOPMENTAL-DISABILITY, SUPPLEMENTAL OXYGEN, PROTECTS, EXPOSURE, ERYTHROPOIETIN, LUNG, PATHOGENESIS, PROTEINS
  • Bursa Uludag University Affiliated: Yes

Abstract

Background/aim: Premature birth is a major problem that results in an increased risk of mortality and morbidity. The management of such infants consists of supraphysiological oxygen therapy, which affects brain development due, in part, to the deterioration caused by reactive oxygen species (ROS). We showed previously that exogenously administered uridine provides neuroprotection in a neonatal rat model of hyperoxic brain injury. Hence, the aim of the present study was to investigate the effects of uridine on ROS in the same setting.