Turkish journal of medical sciences, vol.50, pp.2059-2066, 2020 (SCI-Expanded)
Article / Article
Turkish journal of medical sciences
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
Uridine, hyperoxia, antioxidative, neonatal rat, DJ-1, OXIDATIVE STRESS, CELL-DEATH, DEVELOPMENTAL-DISABILITY, SUPPLEMENTAL OXYGEN, PROTECTS, EXPOSURE, ERYTHROPOIETIN, LUNG, PATHOGENESIS, PROTEINS
Bursa Uludag University Affiliated:
Background/aim: Premature birth is a major problem that results in an increased risk of mortality and morbidity. The management of such infants consists of supraphysiological oxygen therapy, which affects brain development due, in part, to the deterioration caused by reactive oxygen species (ROS). We showed previously that exogenously administered uridine provides neuroprotection in a neonatal rat model of hyperoxic brain injury. Hence, the aim of the present study was to investigate the effects of uridine on ROS in the same setting.