Sex Differences and Drug Dose Influence the Role of the alpha 7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model

AlSharari S. D., Bagdas D., Akbarali H. I., Lichtman P. A., Raborn E. S., Cabral G. A., ...Daha Fazla

NICOTINE & TOBACCO RESEARCH, cilt.19, sa.4, ss.460-468, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1093/ntr/ntw245
  • Dergi Adı: NICOTINE & TOBACCO RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.460-468
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Introduction: alpha 7 nicotinic acetylcholine receptors (nAChRs) play an important role in vagus nerve-based cholinergic anti-inflammatory effects. This study was designed to assess the role of alpha 7 nAChRs in dextran sodium sulfate (DSS)-induced colitis in male and female mouse. We first compared disease activity and pathogenesis of colitis in alpha 7 knockout and wild-type mice. We then evaluated the effect of several alpha 7 direct and indirect agonists on the severity of disease in the DSS-induced colitis.