Sex Differences and Drug Dose Influence the Role of the alpha 7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model

AlSharari S. D., Bagdas D., Akbarali H. I., Lichtman P. A., Raborn E. S., Cabral G. A., ...More

NICOTINE & TOBACCO RESEARCH, vol.19, no.4, pp.460-468, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1093/ntr/ntw245
  • Journal Name: NICOTINE & TOBACCO RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.460-468
  • Bursa Uludag University Affiliated: No

Abstract

Introduction: alpha 7 nicotinic acetylcholine receptors (nAChRs) play an important role in vagus nerve-based cholinergic anti-inflammatory effects. This study was designed to assess the role of alpha 7 nAChRs in dextran sodium sulfate (DSS)-induced colitis in male and female mouse. We first compared disease activity and pathogenesis of colitis in alpha 7 knockout and wild-type mice. We then evaluated the effect of several alpha 7 direct and indirect agonists on the severity of disease in the DSS-induced colitis.