The intermediary role of the central cyclooxygenase / lipoxygenase enzymes in intracerebroventricular injected nesfatin-1-evoked cardiovascular effects in rats

Guvenc-Bayram G., YALÇIN M.

NEUROSCIENCE LETTERS, vol.756, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 756
  • Publication Date: 2021
  • Doi Number: 10.1016/j.neulet.2021.135961
  • Journal Name: NEUROSCIENCE LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Nesfatin-1, Intracerebroventricular, Cyclooxygenase, Lipoxygenase, Mean arterial blood pressure, Heart rate, HEMORRHAGED HYPOTENSIVE RATS, CENTRAL HISTAMINERGIC SYSTEM, BRAIN THROMBOXANE A(2), ARACHIDONIC-ACID, NITRIC-OXIDE, FOOD-INTAKE, INVOLVEMENT, PRESSOR, MELITTIN, RECEPTOR
  • Bursa Uludag University Affiliated: Yes

Abstract

That nesfatin-1 is a neuromodulatory peptide for the cardiovascular system is well documented. Several central receptors have been shown to mediate the cardiovascular effects of nesfatin-1. Immunohistochemistry and Western blot studies showed that nesfatin-1 activated the expression of the central cyclooxygenase (COX) -1, -2 and lipoxygenase (LOX). In addition, microdialysis study showed that nesfatin-1 increased the release of total prostaglandins and leukotrienes from the hypothalamus. The present study investigated whether the central COX and LOX enzymes have a direct mediating role in the MAP and HR responses of nesfatin-1.