NEUROSCIENCE LETTERS, vol.756, 2021 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Nesfatin-1, Intracerebroventricular, Cyclooxygenase, Lipoxygenase, Mean arterial blood pressure, Heart rate, HEMORRHAGED HYPOTENSIVE RATS, CENTRAL HISTAMINERGIC SYSTEM, BRAIN THROMBOXANE A(2), ARACHIDONIC-ACID, NITRIC-OXIDE, FOOD-INTAKE, INVOLVEMENT, PRESSOR, MELITTIN, RECEPTOR
Bursa Uludag University Affiliated:
That nesfatin-1 is a neuromodulatory peptide for the cardiovascular system is well documented. Several central receptors have been shown to mediate the cardiovascular effects of nesfatin-1. Immunohistochemistry and Western blot studies showed that nesfatin-1 activated the expression of the central cyclooxygenase (COX) -1, -2 and lipoxygenase (LOX). In addition, microdialysis study showed that nesfatin-1 increased the release of total prostaglandins and leukotrienes from the hypothalamus. The present study investigated whether the central COX and LOX enzymes have a direct mediating role in the MAP and HR responses of nesfatin-1.